Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
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چکیده
منابع مشابه
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.
It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin-producing beta cell mass in patients with diabetes. We report what we believe to be the first in vivo lineage tracing approach to determine the plasticity potential of pancreatic acinar cells. We developed an acina...
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Pancreatic acinar cell carcinoma (ACC) is a rare malignant neoplasm that accounts for 1-2% of all pancreatic neoplasms. Here we report two cases of ACC and describe their clinical features, the therapies used to treat them, and their prognosis. The first patient was a 65-year-old woman who had an abdominal CT scan for a urinary infection. Fortuitously, a rounded and well-delimited corporeal pan...
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The high level of interest in the pancreatic acinar cell over the past 25 years is a reflection of the fact that this system is a paradigm for the study of protein synthesis, sorting, and secretion. Moreover, pancreatic inflammation is a serious clinical problem that may relate to a disorder in the basic organization of this cell. The discussions by Pandol, Steer, Grendell, and myself are close...
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BACKGROUND & AIMS There have been conflicting results on a cell of origin in pancreatic regeneration. These discrepancies predominantly stem from lack of specific markers for the pancreatic precursors/stem cells, as well as differences in the targeted cells and severity of tissue injury in the experimental models so far proposed. We attempted to create a model that used diphtheria toxin recepto...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2007
ISSN: 0021-9738
DOI: 10.1172/jci29988